Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB.
Investigative ophthalmology & visual science | 25 Oct 2012
EF Gillespie, N Raychaudhuri, KI Papageorgiou, SJ Atkins, Y Lu, LK Charara, T Mester, TJ Smith and RS Douglas
CD40-CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow-derived progenitor cells. The functional consequences of CD40 ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO).
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