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Antisynthetase syndrome: Not just an inflammatory myopathy

OPEN Cleveland Clinic journal of medicine | 3 Oct 2013

S Chatterjee, R Prayson and C Farver
Abstract
In recent years, antisynthetase syndrome has been recognized as an important cause of autoimmune inflammatory myopathy in a subset of patients with polymyositis and dermatomyositis. It is associated with serum antibodies to aminoacyl-transfer RNA synthetases and is characterized by a constellation of manifestations, including fever, myositis, interstitial lung disease, “mechanic’s hands,” Raynaud phenomenon, and polyarthritis. Physicians should be familiar with its variety of clinical presentations and should include it in the differential diagnosis in patients presenting with unexplained interstitial lung disease.
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Concepts
Differential diagnosis, Myopathy, Medical diagnosis, Medical terms, Polymyositis
MeSH headings
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