Transforming Growth Factor-β-Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells
Arteriosclerosis, thrombosis, and vascular biology | 28 Sep 2013
N Zippel, RA Malik, T Frömel, R Popp, E Bess, B Strilic, N Wettschureck, I Fleming and B Fisslthaler
Transforming growth factor-β-activated kinase 1 (TAK1) is a mitogen-activated protein 3-kinase and an AMP-activated protein kinase (AMPK) kinase in some cell types. Although TAK1(-/-) mice display defects in developmental vasculogenesis, the role of TAK1 in endothelial cells has not been investigated in detail.
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