Nature medicine | 31 Mar 2021
M Levine-Tiefenbrun, I Yelin, R Katz, E Herzel, Z Golan, L Schreiber, T Wolf, V Nadler, A Ben-Tov, J Kuint, S Gazit, T Patalon, G Chodick and R Kishony
Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.
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