Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study
OPEN The Lancet. Microbe | 30 Mar 2021
WN Chia, F Zhu, SWX Ong, BE Young, SW Fong, N Le Bert, CW Tan, C Tiu, J Zhang, SY Tan, S Pada, YH Chan, CYL Tham, K Kunasegaran, MI Chen, JGH Low, YS Leo, L Renia, A Bertoletti, LFP Ng, DC Lye and LF Wang
Studies have found different waning rates of neutralising antibodies compared with binding antibodies against SARS-CoV-2. The impact of neutralising antibody waning rate at the individual patient level on the longevity of immunity remains unknown. We aimed to investigate the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.
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