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TD Planche, KA Davies, PG Coen, JM Finney, IM Monahan, KA Morris, L O'Connor, SJ Oakley, CF Pope, MW Wren, NP Shetty, DW Crook and MH Wilcox
Abstract
Diagnosis of Clostridium difficile infection is controversial because of many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic C difficile and gives a positive result more frequently (eg, because of colonisation, which means that individuals can have the bacterium but no free toxin) than does the cytotoxin assay, which detects preformed toxin in faeces. We aimed to validate the reference methods according to clinical outcomes and to derive an optimum laboratory diagnostic algorithm for C difficile infection.
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Concepts
Antibiotic resistance, Diarrhea, Bacteria, Clostridia, Clostridium, Infection, Gut flora, Clostridium difficile
MeSH headings
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