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Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

OPEN The New England journal of medicine | 31 Dec 2020

LR Baden, HM El Sahly, B Essink, K Kotloff, S Frey, R Novak, D Diemert, SA Spector, N Rouphael, CB Creech, J McGettigan, S Kehtan, N Segall, J Solis, A Brosz, C Fierro, H Schwartz, K Neuzil, L Corey, P Gilbert, H Janes, D Follmann, M Marovich, J Mascola, L Polakowski, J Ledgerwood, BS Graham, H Bennett, R Pajon, C Knightly, B Leav, W Deng, H Zhou, S Han, M Ivarsson, J Miller and T Zaks
Abstract
Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
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