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Broadly-targeted autoreactivity is common in severe SARS-CoV-2 Infection

OPEN medRxiv : the preprint server for health sciences | 28 Oct 2020

MC Woodruff, RP Ramonell, FE Lee and I Sanz
Abstract
Severe SARS-CoV-2 infection is linked to the presence of autoantibodies against multiple targets, including phospholipids and type-I interferons. We recently identified activation of an autoimmune-prone B cell response pathway as correlate of severe COVID-19, raising the possibility of de novo autoreactive antibody production during the antiviral response. Here, we identify autoreactive antibodies as a common feature of severe COVID-19, identifying biomarkers of tolerance breaks that may indicate aggressive immunomodulation.
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