Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions
OPEN BMC medicine | 8 Oct 2020
S Rousseaux, E Seyve, F Chuffart, E Bourova-Flin, M Benmerad, MA Charles, A Forhan, B Heude, V Siroux, R Slama, J Tost, D Vaiman, S Khochbin and J Lepeule
Although exposure to cigarette smoking during pregnancy has been associated with alterations of DNA methylation in the cord blood or placental cells, whether such exposure before pregnancy could induce epigenetic alterations in the placenta of former smokers has never been investigated.
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