Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study
OPEN The Lancet. Microbe | 6 Oct 2020
B Schurink, E Roos, T Radonic, E Barbe, CSC Bouman, HH de Boer, GJ de Bree, EB Bulle, EM Aronica, S Florquin, J Fronczek, LMA Heunks, MD de Jong, L Guo, R du Long, R Lutter, PCG Molenaar, EA Neefjes-Borst, HWM Niessen, CJM van Noesel, JJTH Roelofs, EJ Snijder, EC Soer, J Verheij, APJ Vlaar, W Vos, NN van der Wel, AC van der Wal, P van der Valk and M Bugiani
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not only be attributable to a direct virus-induced effect, but also the immune response. The aims of this study were to assess the duration of viral presence, identify the extent of inflammatory response, and investigate the underlying cause of coagulopathy.
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