Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials
OPEN Journal of neurology, neurosurgery, and psychiatry | 22 Jul 2020
JT Yu, W Xu, CC Tan, S Andrieu, J Suckling, E Evangelou, A Pan, C Zhang, J Jia, L Feng, EH Kua, YJ Wang, HF Wang, MS Tan, JQ Li, XH Hou, Y Wan, L Tan, V Mok, L Tan, Q Dong, J Touchon, G Serge, PS Aisen and B Vellas
Evidence on preventing Alzheimer’s disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current evidence with prospective designs to propose evidence-based suggestions on AD prevention.
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