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JC Kwekel, VG Desai, CL Moland, V Vijay and JC Fuscoe
Abstract
The kidney functions in key physiological processes to filter blood and regulate blood pressure via key molecular transporters and ion channels. Sex-specific differences have been observed in renal disease incidence and progression, as well as acute kidney injury in response to certain drugs. Although advances have been made in characterizing the molecular components involved in various kidney functions, the molecular mechanisms responsible for sex differences are not well understood. We hypothesized that the basal expression levels of genes involved in various kidney functions throughout the life cycle will influence sex-specific susceptibilities to adverse renal events.
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Concepts
Genetics, DNA, Renal failure, Blood pressure, Gene expression, Renin, Gene, Kidney
MeSH headings
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