Meta-analysis of secure randomised controlled trials of β-blockade to prevent perioperative death in non-cardiac surgery
OPEN Heart (British Cardiac Society) | 2 Aug 2013
S Bouri, MJ Shun-Shin, GD Cole, J Mayet and DP Francis
Current European and American guidelines recommend the perioperative initiation of a course of β-blockers in those at risk of cardiac events undergoing high- or intermediate-risk surgery or vascular surgery. The Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) family of trials, the bedrock of evidence for this, are no longer secure. We therefore conducted a meta-analysis of randomised controlled trials of β-blockade on perioperative mortality, non-fatal myocardial infarction, stroke and hypotension in non-cardiac surgery using the secure data.
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