Nature medicine | 1 May 2020
QX Long, BZ Liu, HJ Deng, GC Wu, K Deng, YK Chen, P Liao, JF Qiu, Y Lin, XF Cai, DQ Wang, Y Hu, JH Ren, N Tang, YY Xu, LH Yu, Z Mo, F Gong, XL Zhang, WG Tian, L Hu, XX Zhang, JL Xiang, HX Du, HW Liu, CH Lang, XH Luo, SB Wu, XP Cui, Z Zhou, MM Zhu, J Wang, CJ Xue, XF Li, L Wang, ZJ Li, K Wang, CC Niu, QJ Yang, XJ Tang, Y Zhang, XM Liu, JJ Li, DC Zhang, F Zhang, P Liu, J Yuan, Q Li, JL Hu, J Chen and AL Huang
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
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