SciCombinator

Discover the most talked about and latest scientific content & concepts.

KA Selting, CR Sharp, R Ringold and J Knouse
Abstract
Thymidine kinase (TK1) is a biomarker that correlates well with diagnosis and prognosis in certain canine cancers. Canine C-reactive protein (cCRP) is a widely accepted marker of inflammation correlated with increased risk and severity of various diseases. We evaluated serum TK1 and cCRP concentrations in apparently healthy dogs (n = 360). All dogs were followed up for a minimum of 6 months by health questionnaire. All dogs with cancer were identified using a proprietary dual-biomarker algorithm [termed Neoplasia Index (NI)]. Specificity of positive NI is 0.91 and high positive is 0.98. All-cause mortality was 20% in dogs with elevated cCRP and 3% in dogs with low cCRP. The performance of serum TK1 and cCRP as tools for screening for occult cancer is improved when evaluated together. Serum TK1 and cCRP (unified in the NI) are useful in the screening of occult canine cancer. cCRP is useful in screening for other serious diseases.
Tweets*
6
Facebook likes*
0
Reddit*
0
News coverage*
0
Blogs*
1
SC clicks
0
Concepts
Inflammation, Infectious disease, Thymidine kinase 1, Disease, C-reactive protein, Thymidine kinase, Epidemiology, Cancer
MeSH headings
-
comments powered by Disqus

* Data courtesy of Altmetric.com