Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State
Arteriosclerosis, thrombosis, and vascular biology | 3 Jul 2013
JI Borissoff, IA Joosen, MO Versteylen, A Brill, TA Fuchs, AS Savchenko, M Gallant, K Martinod, HT Cate, L Hofstra, HJ Crijns, DD Wagner and BL Kietselaer
Aberrant neutrophil activation occurs during the advanced stages of atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil extracellular traps. This extracellular DNA exerts potent proinflammatory, prothrombotic, and cytotoxic properties. The goal of this study was to examine the relationships among extracellular DNA formation, coronary atherosclerosis, and the presence of a prothrombotic state.
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