AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: A "glycoxidation-centric" point of view
Nutrition, metabolism, and cardiovascular diseases : NMCD | 22 Jun 2013
NC Chilelli, S Burlina and A Lapolla
Advanced glycation end products (AGE) excess is one of the most important mechanisms involved in the pathophysiology of chronic diabetic complications. This review first summarizes the role of these compounds in microvascular pathogenesis, particularly in the light of recently proposed biochemical mechanisms for diabetic retinopathy, nephropathy and neuropathy. Then we focus on the relationship between AGE and metabolic memory, trying to clarify the former’s role in the missing link between micro- and macrovascular complications.
* Data courtesy of Altmetric.com