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NC Chilelli, S Burlina and A Lapolla
Abstract
Advanced glycation end products (AGE) excess is one of the most important mechanisms involved in the pathophysiology of chronic diabetic complications. This review first summarizes the role of these compounds in microvascular pathogenesis, particularly in the light of recently proposed biochemical mechanisms for diabetic retinopathy, nephropathy and neuropathy. Then we focus on the relationship between AGE and metabolic memory, trying to clarify the former’s role in the missing link between micro- and macrovascular complications.
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Concepts
Diabetes, Niacin, Glycated hemoglobin, Blood sugar, Hyperglycemia, Nutrition, Diabetes mellitus, Diabetic retinopathy
MeSH headings
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