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Characterization of Oncolytic Vaccinia Virus Harboring the Human IFNB1 and CES2 Transgenes

OPEN Cancer research and treatment : official journal of Korean Cancer Association | 14 Aug 2019

E Cho, SMBU Islam, F Jiang, JE Park, B Lee, ND Kim and TH Hwang
Abstract
To assess characteristics of SJ-815, a novel oncolytic vaccinia virus lacking a functional thymidine kinase-encoding tk gene, and instead, having two human transgenes: the IFNB1 that encodes interferon beta 1, and the CES2 that encodes carboxylesterase 2, which metabolizes the prodrug, irinotecan, into cytotoxic SN-38.
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