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Time to positivity (TTP) of neonatal blood cultures: a trend analysis over a decade from Ireland

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | 11 May 2019

D Huggard, J Powell, C Kirkham, L Power, N O'Connell and RK Philip
Abstract
Blood culture (BC) remains gold standard for the evaluation and diagnosis of neonatal sepsis. Time when BC becomes positive and the type of microorganism isolated are crucial in deciding the antimicrobial management. Likely pathogenicity of organisms growing in BC could potentially be predicted based on the “time to positivity” (TTP). We aimed to estimate the predictive value of isolating a likely pathogenic organism depending on TTP; evaluate the aetiological trend and neonatal mortality rate due to culture proven neonatal sepsis for over a decade and verify whether the application of a “36 hour rule” to discontinue empiric antibiotics in newborn infants with negative BC would be safe.
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