A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer
OPEN BMC cancer | 11 Feb 2019
ME Penney, PS Parfrey, S Savas and YE Yilmaz
Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis.
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