OPEN PLoS medicine | 23 Jan 2019
A Gordon, L Gresh, S Ojeda, LC Katzelnick, N Sanchez, JC Mercado, G Chowell, B Lopez, D Elizondo, J Coloma, R Burger-Calderon, G Kuan, A Balmaseda and E Harris
Zika virus (ZIKV) emerged in northeast Brazil in 2015 and spread rapidly across the Americas, in populations that have been largely exposed to dengue virus (DENV). The impact of prior DENV infection on ZIKV infection outcome remains unclear. To study this potential impact, we analyzed the large 2016 Zika epidemic in Managua, Nicaragua, in a pediatric cohort with well-characterized DENV infection histories.
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