A simulation-based method to determine optimal sampling schedules for dosimetry in radioligand therapy
Zeitschrift fur medizinische Physik | 7 Jan 2019
A Rinscheid, J Lee, P Kletting, AJ Beer and G Glatting
For dosimetry in radioligand therapy, the time-integrated activity coefficients (TIACs) for organs at risk and for tumour lesions have to be determined. The used sampling scheme affects the TIACs and therefore the calculated absorbed doses. The aim of this work was to develop a general and flexible method, which analyses numerous clinically applicable sampling schedules using true time-activity curves (TACs) of virtual patients.
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