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M Lommatzsch, S Korn, R Buhl and JC Virchow
Abstract
For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
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Concepts
Atopy, Hygiene hypothesis, Immunology, Clinical trial, Immunoglobulin E, Allergy, Asthma, Immune system
MeSH headings
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