Effect of contrast agent dosage on longitudinal relaxation time, signal and apparent tumor volume in glioblastoma at 9.4T
Zeitschrift fur medizinische Physik | 25 Nov 2018
A Nickel, D Milford, M Fischer, M Bendszus and S Heiland
Glioblastoma multiforme is the most frequent innate brain tumor and still yields an unfavorable prognosis of 15 months of survival after diagnosis. Animal models play an important role in the investigation of therapeutic strategies of brain tumors. Thereby, MRI is substantial to individual follow-up examination for therapeutic response. Contrast agent dosage at 1.5 and 3T MRI has been thoroughly tested, while there is hardly any data for 9.4T. Therefore, the aim of this study was to find the optimal contrast agent dosage at 9.4T for examination of T1 relaxation time and apparent tumor volume in an animal model.
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