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Immunotherapy failure in adrenocortical cancer: where next?

OPEN Endocrine connections | 8 Nov 2018

D Cosentini, S Grisanti, A Dalla Volta, M Laganà, C Fiorentini, P Perotti, S Sigala and A Berruti
Abstract
Excerpt: Adrenocortical carcinoma (ACC) is a rare endocrine neoplasia, characterized by an overall dismal prognosis and its clinical manifestations are the consequence of either steroid excess or tumor mass progression. Surgery is the mainstay of therapy. For patients with locally advanced or metastatic ACC, not amenable to surgery, Mitotane and cytotoxic chemotherapy (with etoposide, doxorubicin and cisplatin - EDP scheme) are the systemic treatments currently in use.
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