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MJ Yousefzadeh, Y Zhu, SJ McGowan, L Angelini, H Fuhrmann-Stroissnigg, M Xu, YY Ling, KI Melos, T Pirtskhalava, CL Inman, C McGuckian, EA Wade, JI Kato, D Grassi, M Wentworth, CE Burd, EA Arriaga, WL Ladiges, T Tchkonia, JL Kirkland, PD Robbins and LJ Niedernhofer
Abstract
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combination of dasatinib and the flavonoid quercetin is a potent senolytic improving numerous age-related conditions including frailty, osteoporosis and cardiovascular disease. The goal of this study was to identify flavonoids with more potent senolytic activity.
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