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Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling

OPEN Journal of Korean Neurosurgical Society | 12 Jul 2018

JC Park, IB Chang, JH Ahn, JH Kim, JH Song, SM Moon and YH Park
Abstract
Notch receptors are heterodimeric transmembrane proteins that regulate cell fate, such as differentiation, proliferation, and apoptosis. Dysregulated Notch pathway signaling has been observed in glioblastomas, as well as in other human malignancies. Nerve growth factor (NGF) is essential for cell growth and differentiation in the nervous system. Recent reports suggest that NGF stimulates glioblastoma proliferation. However, the relationship between NGF and Notch1 in glioblastomas remains unknown. Therefore, we investigated expression of Notch1 in a glioblastoma cell line (U87-MG), and examined the relationship between NGF and Notch1 signaling.
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