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Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles

International journal of radiation oncology, biology, physics | 27 Feb 2018

JR Eisenbrey, R Shraim, JB Liu, J Li, M Stanczak, B Oeffinger, DB Leeper, SW Keith, LJ Jablonowski, F Forsberg, P O'Kane and MA Wheatley
Abstract
Much of the volume of solid tumors typically exists in a chronically hypoxic microenvironment that has been shown to result in both chemotherapy and radiation therapy resistance. The purpose of this study was to use localized microbubble delivery to overcome hypoxia prior to therapy.
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