Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action
OPEN Menopause (New York, N.Y.) | 14 Mar 2018
JK Prague, RE Roberts, AN Comninos, S Clarke, CN Jayasena, P Mohideen, VH Lin, TP Stern, N Panay, MS Hunter, LC Webber and WS Dhillo
Seventy percent of postmenopausal women experience vasomotor symptoms, which can be highly disruptive and persist for years. Hormone therapy and other treatments have variable efficacy and/or side effects. Neurokinin B signaling increases in response to estrogen deficiency and has been implicated in hot flash (HF) etiology. We recently reported that a neurokinin 3 receptor (NK3R) antagonist reduces HF in postmenopausal women after 4 weeks of treatment. In this article we report novel data from that study, which shows the detailed time course of this effect.
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