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JK Prague, RE Roberts, AN Comninos, S Clarke, CN Jayasena, P Mohideen, VH Lin, TP Stern, N Panay, MS Hunter, LC Webber and WS Dhillo
Abstract
Seventy percent of postmenopausal women experience vasomotor symptoms, which can be highly disruptive and persist for years. Hormone therapy and other treatments have variable efficacy and/or side effects. Neurokinin B signaling increases in response to estrogen deficiency and has been implicated in hot flash (HF) etiology. We recently reported that a neurokinin 3 receptor (NK3R) antagonist reduces HF in postmenopausal women after 4 weeks of treatment. In this article we report novel data from that study, which shows the detailed time course of this effect.
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Concepts
Effectiveness, Receptor antagonist, Menopause, Receptor
MeSH headings
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