Combination of biomarkers of vascular calcification and sTWEAK to predict cardiovascular events in chronic kidney disease
Atherosclerosis | 7 Feb 2018
M Bozic, N Méndez-Barbero, C Gutiérrez-Muñoz, A Betriu, J Egido, E Fernández, JL Martín-Ventura, JM Valdivielso and LM Blanco-Colio
Vascular calcification (VC) and atherosclerosis are associated with an increased cardiovascular morbimortality in chronic kidney disease (CKD). Osteoprotegerin (OPG) and osteopontin (OPN) are involved in both VC and CKD. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) has been related to cardiovascular disease. We hypothesized that OPG, OPN and sTWEAK levels may be associated with a higher prevalence of cardiovascular outcomes in patients with CKD.
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