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Emerging Therapies for Atopic Dermatitis: The Prostaglandin/Leukotriene Pathway

Journal of the American Academy of Dermatology | 19 Dec 2017

DA Yanes and JL Mosser-Goldfarb
Abstract
The role of leukotrienes and prostaglandins in development of atopy has been prototypically established in studies of asthma pathogenesis. Likewise, both in vitro and in vivo studies of atopic dermatitis have demonstrated that these molecules maintain important pathophysiologic roles. Thus, it follows that targeted therapies against these molecules may be promising in management of atopic dermatitis. Montelukast has had questionable efficacy in patients with atopic dermatitis, while small pilots using zileuton did have some clinically significant improvement. There are several agents in development that target leukotrienes and/or prostaglandins as well, including OC000459, Q301, and ZPL-521. In atopic dermatitis, OC000459 did not demonstrate efficacy in clinical trials, and the efficacy of the other two agents remains to be seen. Should these medications prove promising, these topical agents may play a future role in chronic maintenance therapy and flare prophylaxis in atopic dermatitis, as anti-leukotriene therapy does in asthma.
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Concepts
In vitro, Montelukast, Medicine, Inflammation, Allergy, Atopy, In vivo, Asthma
MeSH headings
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