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VS Mathur, J Kumar, PW Crawford, H Hait and T Sciascia
Abstract
Pruritus is a distressing hallmark of the uremic condition, affecting approximately 60% of hemodialysis patients. Abnormal endogenous opioid ligand activity at μ and κ-opioid receptors has been postulated as a mechanism in uremic pruritus. Nalbuphine is a μ-opioid antagonist and κ-opioid agonist.
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Concepts
Opioids, Nalbuphine, Opioid receptor, Inverse agonist, Receptor, Opioid, Buprenorphine, Receptor antagonist
MeSH headings
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