Opioid-induced inhibition of the human serotonin and norepinephrine transporters in vitro: link to clinical reports of serotonin syndrome
OPEN British journal of pharmacology | 7 Dec 2017
A Rickli, E Liakoni, MC Hoener and ME Liechti
Opioids may inhibit the serotonin and norepinephrine transporters (SERT and NET, respectively). NET inhibition may contribute to analgesia, and SERT inhibition or interactions with serotonin receptors may cause serotonergic toxicity. However, the effects of different opioids on the human SERT, NET, and serotonin receptors have not been sufficiently studied.
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