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CA Class, MJ Ha, V Baladandayuthapani and KA Do
Abstract
Differential network analysis is an important way to understand network rewiring involved in disease progression and development. Building differential networks from multiple `omics data provides insight into the holistic differences of the interactive system under different patient-specific groups. DINGO was developed to infer group-specific dependencies and build differential networks. However, DINGO and other existing tools are limited to analyze data arising from a single platform, and modeling each of the multiple ‘omics data independently does not account for the hierarchical structure of the data.
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Concepts
Heterarchy, Computer network, Functional genomics, Building, Differential, Hierarchy, Structure
MeSH headings
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