Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience
OPEN Genome medicine | 1 Dec 2017
PG Ridge, CM Karch, S Hsu, I Arano, CC Teerlink, MTW Ebbert, JD Gonzalez Murcia, JM Farnham, AR Damato, M Allen, X Wang, O Harari, VM Fernandez, R Guerreiro, J Bras, J Hardy, R Munger, M Norton, C Sassi, A Singleton, SG Younkin, DW Dickson, TE Golde, ND Price, N Ertekin-Taner, C Cruchaga, AM Goate, C Corcoran, J Tschanz, LA Cannon-Albright and JSK Kauwe
While age and the APOE ε4 allele are major risk factors for Alzheimer’s disease (AD), a small percentage of individuals with these risk factors exhibit AD resilience by living well beyond 75 years of age without any clinical symptoms of cognitive decline.
* Data courtesy of Altmetric.com