Journal of the American Chemical Society | 3 Apr 2013
MM Smulders, S Zarra and JR Nitschke
We report a detailed binding study addressing both the thermodynamics and kinetics of binding of a large set of guest molecules - with widely varying properties - to a water-soluble metal-organic M4L6 host. The effects of different guest properties upon binding strength and kinetics are elucidated by a systematic analysis of the binding data through principal component analysis, thus allowing for structure-property relationships to be determined. These insights allowed us to design more complex encapsulation sequences, in which multiple guests, added simultaneously, are bound and released by the host in a time-dependent manner, thus allowing multiple states of the system to be accessed sequentially. Moreover, by inclusion of the pH-sensitive guest pyridine we were able to further extend our control over binding by creating a reversible pH-controlled three-guest sequential binding cycle.
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