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ST Uh, SM Koo, Y Kim, K Kim, S Park, AS Jang, D Kim, YH Kim and CS Park
Abstract
Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome. In this study, we elucidated whether NLRP3 -inf lammasome is activated by DEPs and whether antioxidants (N-acetylcysteine [NAC]) could inhibit such activation.
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Concepts
Lung, Oxidative phosphorylation, Mitochondrion, Protein, Reactive oxygen species, Gasoline, Oxygen, Glutathione
MeSH headings
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