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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies

OPEN CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 19 Jul 2017

MB Azad, AM Abou-Setta, BF Chauhan, R Rabbani, J Lys, L Copstein, A Mann, MM Jeyaraman, AE Reid, M Fiander, DS MacKay, J McGavock, B Wicklow and R Zarychanski
Abstract
Nonnutritive sweeteners, such as aspartame, sucralose and stevioside, are widely consumed, yet their long-term health impact is uncertain. We synthesized evidence from prospective studies to determine whether routine consumption of non-nutritive sweeteners was associated with long-term adverse cardiometabolic effects.
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Concepts
Sweeteners, Sugar substitute, Sucralose, Clinical trial, Evidence-based medicine, Systematic review, Randomized controlled trial, Epidemiology
MeSH headings
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