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Role of Gut Microbiota in Rheumatoid Arthritis

OPEN Journal of clinical medicine | 10 Jun 2017

Y Maeda and K Takeda
Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that supports the role of the gut microbiota in RA. We and others have demonstrated that the abundance of Prevotella copri is increased in some early RA. We have also used gnotobiotic experiments to show that dysbiosis in RA patients contributed to the development of Th17 cell-dependent arthritis in intestinal microbiota-humanized SKG mice. On the other hand, Prevotella histicola from human gut microbiota suppressed the development of arthritis. In summary, Prevotella species are involved in the pathogenesis of arthritis.
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Concepts
Human, Autoimmunity, Systemic autoimmune diseases, Bacteria, Gut flora, Immune system, Rheumatology, Rheumatoid arthritis
MeSH headings
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