SciCombinator

Discover the most talked about and latest scientific content & concepts.

W Liu, A Klose, S Forman, ND Paris, L Wei-LaPierre, M Cortés-Lopéz, A Tan, M Flaherty, P Miura, RT Dirksen and JV Chakkalakal
Abstract
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response to denervation (1). Here, we examined gene expression profiles and neuromuscular junction integrity in aged mouse muscles, and unexpectedly found limited denervation despite a high level of degenerated neuromuscular junctions. Instead, degenerated neuromuscular junctions were associated with reduced contribution from muscle stem cells. Indeed, muscle stem cell depletion was sufficient to induce neuromuscular junction degeneration at a younger age. Conversely, prevention of muscle stem cell and derived myonuclei loss was associated with attenuation of age-related neuromuscular junction degeneration, muscle atrophy, and the promotion of aged muscle force generation. Our observations demonstrate that deficiencies in muscle stem cell fate and post-synaptic myogenesis provide a cellular basis for age-related neuromuscular junction degeneration and associated skeletal muscle decline.
Tweets*
19
Facebook likes*
2
Reddit*
0
News coverage*
12
Blogs*
3
SC clicks
0
Concepts
Action potential, Cell, Skeletal muscle, Muscle, Neuromuscular junction, Muscle atrophy, Gene, Acetylcholine
MeSH headings
-
comments powered by Disqus

* Data courtesy of Altmetric.com