Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema
OPEN The Journal of allergy and clinical immunology | 10 May 2017
MS Elias, HA Long, CF Newman, PA Wilson, A West, PJ McGill, KC Wu, MJ Donaldson and NJ Reynolds
Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein, strongly predispose to AE; however, the precise role of FLG deficiency in AE pathogenesis remains incompletely understood.
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