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Reversibility of Vasalgel™ male contraceptive in a rabbit model

OPEN Basic and clinical andrology | 19 Apr 2017

D Waller, D Bolick, E Lissner, C Premanandan and G Gamerman
Abstract
Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset. This study evaluates the capacity to restore sperm concentrations in ejaculates after a reversal procedure.
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Concepts
Sexual intercourse, Sex education, Menstrual cycle, Reproduction, Birth control, Abortion, Pregnancy
MeSH headings
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