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R Valenzuela, F Echeverria, M Ortiz, MÁ Rincón-Cervera, A Espinosa, MC Hernandez-Rodas, P Illesca, A Valenzuela and LA Videla
Abstract
Eicosapentaenoic acid (EPA, C20:5n-3), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, C20:4n-6) are long-chain polyunsaturated fatty acids (LCPUFAs) with relevant roles in the organism. EPA and DHA are synthesized from the precursor alpha-linolenic acid (ALA, C18:3n-3), whereas AA is produced from linoleic acid (LA, C18:2n-6) through the action of Δ5 and Δ6-desaturases. High-fat diet (HFD) decreases the activity of both desaturases and LCPUFA accretion in liver and other tissues. Hydroxytyrosol (HT), a natural antioxidant, has an important cytoprotective effects in different cells and tissues.
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Concepts
Omega-6 fatty acid, Arachidonic acid, Nutrition, Essential fatty acid, Fatty acid, Linoleic acid, Eicosapentaenoic acid, Fatty acids
MeSH headings
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