Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
OPEN PLoS medicine | 23 Mar 2017
SG Snowden, AA Ebshiana, A Hye, Y An, O Pletnikova, R O'Brien, J Troncoso, C Legido-Quigley and M Thambisetty
The metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly understood. Omega-3 and -6 fatty acids have previously been linked to both protective and pathogenic effects in AD. However, to date little is known about how the abundance of these species is affected by differing levels of disease pathology in the brain.
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