OPEN Journal of neuroinflammation | 16 Mar 2017
A Kumar, BA Stoica, DJ Loane, M Yang, G Abulwerdi, N Khan, A Kumar, SR Thom and AI Faden
Local and systemic inflammatory responses are initiated early after traumatic brain injury (TBI), and may play a key role in the secondary injury processes resulting in neuronal loss and neurological deficits. However, the mechanisms responsible for the rapid expansion of neuroinflammation and its long-term progression have yet to be elucidated. Here, we investigate the role of microparticles (MP), a member of the extracellular vesicle family, in the exchange of pro-inflammatory molecules between brain immune cells, as well as their transfer to the systemic circulation, as key pathways of inflammation propagation following brain trauma.
* Data courtesy of Altmetric.com