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Successful Treatment of Human Plague with Oral Ciprofloxacin

OPEN Emerging infectious diseases | 27 Jan 2017

T Apangu, K Griffith, J Abaru, G Candini, H Apio, F Okoth, R Okello, J Kaggwa, S Acayo, G Ezama, B Yockey, C Sexton, M Schriefer, EK Mbidde and P Mead
Abstract
The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.
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Concepts
Pasteur Institute, Third Pandemic, Bacterial diseases, Pneumonic plague, Plague, Bubonic plague, Black Death, Yersinia pestis
MeSH headings
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