Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system
OPEN Gut | 24 Feb 2017
L Becker, L Nguyen, J Gill, S Kulkarni, PJ Pasricha and A Habtezion
The enteric nervous system (ENS) undergoes neuronal loss and degenerative changes with age. The cause of this neurodegeneration is poorly understood. Muscularis macrophages residing in close proximity to enteric ganglia maintain neuromuscular function via direct crosstalk with enteric neurons and have been implicated in the pathogenesis of GI motility disorders like gastroparesis and postoperative ileus. The aim of this study was to assess whether ageing causes alterations in macrophage phenotype that contributes to age-related degeneration of the ENS.
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