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Topical application of recombinant activated factor VII during cesarean section for placenta previa

OPEN American journal of obstetrics and gynecology | 22 Feb 2017

BT Schjoldager, E Mikkelsen, MR Lykke, J Præst, AM Hvas, L Heslet, NJ Secher, JD Salvig and N Uldbjerg
Abstract
During cesarean delivery in patients with placenta previa, hemorrhaging after removal of the placenta is often challenging. In this condition, the extraordinarily high concentration of tissue factor at the placenta site may constitute a principal of treatment as it activates coagulation very effectively. The presumption, however, is that tissue factor is bound to activated factor VII (FVIIa).
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Concepts
Placental abruption, Obstetrics, Factor VII, Caesarean section, Placenta praevia, Placenta accreta, Childbirth
MeSH headings
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