SciCombinator

Discover the most talked about and latest scientific content & concepts.

A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies

OPEN Journal of the American College of Cardiology | 12 Feb 2017

S Tsimikas
Abstract
Evidence that elevated lipoprotein(a) (Lp[a]) levels contribute to cardiovascular disease (CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform-independent assays, in concert with genetic, epidemiological, translational, and pathophysiological insights, have established Lp(a) as an independent, genetic, and likely causal risk factor for CVD and CAVS. These observations are consistent across a broad spectrum of patients, risk factors, and concomitant therapies, including patients with low-density lipoprotein cholesterol¬†<70 mg/dl. Statins tend to increase Lp(a) levels, possibly contributing to the "residual risk" noted in outcomes trials and at the bedside. Recently approved proprotein convertase subtilisin/kexin-type 9 inhibitors and mipomersen lower Lp(a) 20% to 30%, and emerging RNA-targeted therapies lower Lp(a) >80%. These approaches will allow testing of the “Lp(a) hypothesis” in clinical trials. This review summarizes the current landscape of Lp(a), discusses controversies, and reviews emerging therapies to reduce plasma Lp(a) levels to decrease risk of CVD and CAVS.
Tweets*
121
Facebook likes*
3
Reddit*
0
News coverage*
3
Blogs*
0
SC clicks
0
Concepts
Low-density lipoprotein, Aortic valve stenosis, Avicenna, Risk factor, The Canon of Medicine, Cardiovascular disease, Epidemiology, Atherosclerosis
MeSH headings
-
comments powered by Disqus

* Data courtesy of Altmetric.com