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DW Kang, JB Adams, AC Gregory, T Borody, L Chittick, A Fasano, A Khoruts, E Geis, J Maldonado, S McDonough-Means, EL Pollard, S Roux, MJ Sadowsky, KS Lipson, MB Sullivan, JG Caporaso and R Krajmalnik-Brown
Abstract
Autism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 10(13) bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with ASD. The gut microbiome-ASD connection has been tested in a mouse model of ASD, where the microbiome was mechanistically linked to abnormal metabolites and behavior. Similarly, a study of children with ASD found that oral non-absorbable antibiotic treatment improved GI and ASD symptoms, albeit temporarily. Here, a small open-label clinical trial evaluated the impact of Microbiota Transfer Therapy (MTT) on gut microbiota composition and GI and ASD symptoms of 18 ASD-diagnosed children.
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Concepts
Pervasive developmental disorder, Digestive system, Autism spectrum, Asperger syndrome, Escherichia coli, Autism, Gut flora, Bacteria
MeSH headings
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